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THE WELLNESS CHRONICLES

Researchers Believe Declining NAD Levels May Be the Central Cause of Nearly Every Aging Complaint After 40.

Written by Sarah Mitchell ⎸ Health & Wellness Writer

This health writer breaks down what longevity researchers say may be the most overlooked discovery in aging science.

Published on March 13, 2026

If you've been following the latest aging trends you've probably heard of NAD+.

Scientists have been studying it quietly for years.

And what they found finally explains what millions of people over 40 are experiencing.

Weight creeping up no matter how clean you eat.

Energy disappearing by early afternoon no matter how much you sleep.

Joints instantly aching when you wake up.

Losing your drive and your mood changing every second.

Wrinkles and sagging appearing on your face.

Your hair getting thinner.

Most people go through these changes one by one and blame anything:

Diet. Stress. Age. Hormones. Genetics.

You go see a doctor but your bloodwork comes out "normal".

So you go back home with no real explanation and no real solution.

Researchers found these problems all lead to one specific deficiency...

What scientists found at the cellular level

Every cell in your body runs on energy.

Not the kind of energy you feel after coffee.

Real cellular energy produced deep inside your mitochondria.

This process depends entirely on NAD+.

It's not a vitamin and it's not a hormone.

It sits at the centre of every energy, repair and regulation system in our bodies.

It powers proteins that control your metabolism and fat burning.

Fuels enzymes that repair your DNA and keep your cells clean.

Tells your body when to rest, recover and rebuild.

Keeps inflammation away from your joints, skin and everywhere else in your body.

And stabilizes your hormones.

Without enough NAD+ your body can't function properly.

After turning 40, NAD+ levels drops by 50%.

By mid-50s most people only have a fraction left of what their body had at 30.

This is the real reason behind all those changes.

You aren't "just getting older".

What Happens Deep Inside Your Cells When NAD+ Drops

Your cells don't all fail at once.

Over time they become less and less efficient.

For metabolism, NAD+ powers a protein called SIRT1 which regulates fat burning.

So when NAD+ levels drop your body stops burning fat and starts storing it. (especially around your belly)

For your energy system NAD+ is the molecule that carries ATP throughout your entire body.

ATP is our body's energy currency.

So low NAD+ levels causes low ATP production making you always feel drained.

For joints, NAD+ fuels repair proteins stopping inflammation and rebuilding tissue after wear.

In terms of hormones, NAD+ plays a direct role in how your cells respond to hormonal signals.

When NAD+ levels decline those signals weaken.

Which is why you feel off even if your bloodwork comes in as "normal".

Lastly for your skin and hair.

Skin relies on cells that produce collagen and elastin to maintain its structure.

And hair follicles have the same fate.

Both need NAD+ to power the energy allowing them to keep building and repairing.

All different problems.

Same root cause.

Why does this happen?

First, cells accumulate daily damage from:

- Stress

- Toxins.

- Daily wear and tear.

To repair those damages your body sends enzymes which consume NAD+.

Second, an enzyme called CD38 becomes more active with age.

Its job is to break down NAD+.

Older tissue contains 2-3x more of it than younger tissue.

Third, your body becomes less efficient at making and recycling NAD+.

This system slows down.

Then starts producing less NAD+ while using more of it.

Together, these processes slowly drain your NAD+ reserves.

By the time you notice any effects the damage has already been building for years...

What scientists discovered: the NAD+ messenger

Our bodies don't produce NAD+.

They build it using a natural compound called NMN.

Or Nicotinamide mononucleotide.

NMN exists naturally in the body and can be found in trace amounts in certain foods.

It enters your cells to then transform into NAD+.

So why not just take NAD+ directly?

Researchers tried that.

The problem is NAD+ molecules are too big to pass through cell membranes on their own.

Most of it would just get broken down by digestion before it even reaches your cells.

NMN is way smaller and actually gets through cell membranes.

In clinical trials, researchers gave NMN to aging subjects.

They're NAD+ levels increased by up to 38% in just weeks.

NMN doesn't spike and crash your energy like caffeine.

It doesn't suppress appetite.

And it doesn't block or force anything.

It simply gives your cells what they need to produce more NAD+.

For most people this can change everything.

Benefits of High NAD+ Levels

When NAD+ levels rise, researchers noticed it wasn't one benefit, it was multiple.

Energy stabilizes.

No more crashing in the afternoon.

Metabolism starts working again.

Cravings and stubborn belly fat start going away.

Joints stop hurting.

Morning stiffness goes away in minutes instead of hours.

Drive and vitality return.

Skin health improves.

Softer skin and fine lines start fading away.

Hair health improves.

Hair starts growing and gets thicker.

Grey hairs slow down and dark pigment returns at the roots.

Better sleep.

Boosting NAD+ levels supports your circadian rhythm which affects sleep quality.

You'll notice a boost in energy within the first week.

And within 2-4 weeks you'll start seeing more of these benefits appear.

But the real magic begins after the three-month mark.

The key is to stay consistent.

What To Know Before Buying NMN

Not all NMN is what it claims to be.

An independent study tested 22 top-selling NMN supplements.

They found out 64% of them contained less than 1% of the NMN stated on the label.

Meaning the majority of people who tried NMN and felt nothing weren't actually taking NMN.

That's why people say NMN "doesn't work".

The product failed them, not NMN.

But purity is only part of the problem.

Even high-quality NMN on its own may not be enough.

Researchers studying NMN found it works best with the right supporting ingredients.

These ingredients help protect NAD+ from being broken down too quickly.

But they also help get better and faster results.

The best formulas are built to efficiently raise NAD+ and make sure your cells can actually use it.

Introducing CLERO's 10-in-1 NMN

CLERO solves both of those issues.

Every batch uses independently tested, verified high-purity NMN.

No misleading labels and no hiding what's actually inside.

CLERO doesn't stop there.

Alongside NMN CLERO includes 9 other carefully chosen ingredients.

Each one addresses a specific part of what happens when your body ages at the cellular level.

And all it takes is one capsule a day.

CHECK AVAILABILITY

Join 2,000+ People Who Stopped Guessing

Right now there are two kinds of people over 40.

Those still trying to figure out why nothing works.

Still cutting carbs.

Still dragging themselves to the gym.

Still spending money on supplements that sit half-finished in the cupboard.

Still waking up tired.

And still crashing by 3pm.

Then there's the people who found the answer.

Who wake up with steady energy and don't think twice about it.

Who move through the afternoon without hitting a wall.

Who have more driven than in their 20's.

Who feel younger than ever.

And who are getting compliments daily on how good they look.

Over 2,000 people have already made that switch with CLERO NMN.

They didn't find a magic pill.

They found the missing piece their cells had been waiting for.

Which side of that line do you want to be on?

CHECK AVAILABILITY

CLERO's Once In A Lifetime Offer

CLERO's NMN supplement is now available for $0.83 a day.

Less than a dollar a day.

That's $49.99 for one 2-months supply bottle.

Buy 2 bottles or more and get FREE shipping.

On top of that, CLERO's NMN comes with a 180-day money-back guarantee.

So you can try 3 bottles of CLERO's NMN risk-free.

If you're still crashing by 3pm...

Not losing weight...

Waking up with aching joints that lasts hours...

Still have fine lines and wrinkles...

Can't sleep through the night...

Or just don't like the way our bottle looks.

You get every penny back no questions asked.

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what people who've tried clero are saying

By week 3 I noticed I was making it through the afternoon without needing to lie down or have a third coffee. After 2 months my husband asked what I was doing differently. I hadn't told him I'd started anything. And that told me everything...

Karen J.

Verified Buyer

I started taking it for energy. About a month in I realized I was getting up from my desk without thinking about my knee. That hadn't happened in over a year. I wasn't even taking it for that.

Robert T.

Verified Buyer

My hairdresser asked what I'd changed. She said my hair felt different and fuller than usual. That was four months in. I nearly cried in the chair. Whatever is happening, I'm not stopping.

Linda M.

Verified Buyer

The skin thing surprised me. I wasn't expecting that. Someone at work asked if I'd changed my skincare routine. I haven't touched my skincare. I just started this and I LOOK 10 YEARS YOUNGER!!!

Diane A.

Verified Buyer

I was super skeptical. I've boughten cheap NMN on Amazon twice and felt absolutely nothing both times. This was completely different. I can finally sleep at night without constantly waking up.

David E.

Verified Buyer

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Claire D.

Verified Buyer

My joint pain isn't gone but I feel a lot better. I walked the full canal path with my wife last Saturday. I haven't done that without intense knee pain for the last 2 years. CLERO is a lifesaver!

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Verified Buyer

CLERO NMN is one of the few NMN supplements independently verified to contain what the label actually says.

Every batch is tested for purity and potency. CLERO's 10-ingredient NAD+ support formula combines clinically studied ingredients shown to raise NAD+ levels. All in one capsule a day.

Over 2,000+ people have reported improvements in energy, mental clarity, metabolism, and overall vitality.

"Here are the results people are experiencing:"

Elizabeth Reyes

Austin, TX

"I want to say something to anyone reading this who has chronic pain and is skeptical of supplements because I was you. I've had back problems for years. I was on anti-inflammatories for so long they started causing stomach issues and I had to stop. My daughter found CLERO and basically made me try it, I didn't expect much... After 2 months and one bottle down I was able to spend hours in the garden again, bending, on my knees, getting up and down. All without any pain! I didn't even think about my back, not even once. That was six months ago and I'm still on it. I recommend this to everyone!"

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Dr. Claire Whitfield, MD

Denver, CO

"I've looked closely at what CLERO has put together and I have to give them credit. The transparency around ingredients and testing is exactly what's been missing in this category. Most NMN products on the market are not what they claim to be. CLERO is one of the few I've seen that takes the quality side seriously. Their 10-ingredient formula is also worth noting. If my patients are going to take an NMN supplement, this is the one I point them toward."

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Jason Mercer

Chicago, IL

"I'm 42 and I train 5 days a week. I have been for 15 years. So when I started recovering slower than when I first started working out I knew something was wrong. I was getting 7-8 hours of sleep, my diet was on point and I was going as hard as usual in my workouts. Sometimes it'd take me up to 3 days to feel normal again. I even started getting weaker. That's when I heard about NAD+ and how it drops when you get older. It made complete sense so I looked for the best supplement I could take and found CLERO's NMN. After taking it for around 6 weeks I'm now able to train for 4 days in a row and feel completely fine. My gym partner even thought I was on TRT lol. Thanks to CLERO it feels like I'm back in my prime."

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